Mark D’Esposito (UC-Berkeley) Natalie C. Ebner (University of Florida) Linda Henkel (Fairfield University) Julie A. Higgins (Manhattanville College) Steve Lindsay (University of Victoria) Keith Lyle (University of Louisville) Mara Mather (University of Southern California) Karen J. Mitchell (West Chester University) J.J. Qin (CSU-Sacramento) Speaker: Mark D'Esposito, MD Professor of Neuroscience and Psychology, University of California, Berkeley, USA. The new chemical shift reference is now being used to determine accurate spectral information – a basis set – on more than fifty compounds expected to be present in a human brain. I am trained as a cognitive neuroscientist and experimental psychologist. The D'Esposito Lab is a cognitive neuroscience research laboratory within the. I use methods such as structural and functional MRI, perfusion and diffusion MRI, and spectroscopy. Mark has challenged me to think fully about questions that I had thought were outside my arena. Relatively intact value processing was also confirmed using DDM mixture models, which revealed that in both groups >98% of trials were better accounted for by a DDM with value modulation than by a null model without value modulation. At present, I am developing methods to study glucose metabolism, brain thermometry, and the brain-gut axis. Building on this previous work, we implemented the DDM as the choice rule in inter-temporal choice (temporal discounting) and risky choice (probability discounting) using hierarchical Bayesian parameter estimation. Jacobs completed her thesis in the lab of Mark D’Esposito on the effects of estrogen on dopamine-dependent cognitive processes. A time varying magnetic field, produced by a coil placed on the head, induces an electric field within the brain which couples to neurons and potentially affects their short and long term behavior. Gary R Turner 1 , Tatjana Novakovic-Agopian 2 3 , Erica Kornblith 3 , Areeba Adnan 1 , Michelle Madore 4 , Anthony J W Chen 5 6 , Mark D'Esposito 5 Affiliations 1 York University, Toronto, Canada. I am a recent graduate from the Psychology Specialist program at the University of Toronto. My research aims to provide insights into brain metabolism in healthy aging using advanced 1 H MR spectroscopy (MRS) methods. Emily Goard Jacobs and Michael Jacobs Goard are alumni from the Neuroscience PhD Program entering class of 2004. Emily Jacobs and Mark D’Esposito, Estrogen Shapes Dopamine-Dependent Cognitive Processes: Implications for Women’s Health, The Journal of Neuroscience, April 6, 2011 • 31(14):5286 –5293. Abstract: A fundamental question in cognitive neuroscience is how we are able to flexibly guide our behavior. Director Mark D'Esposito, MD Professor of Neuroscience & Psychology Dr. Lana Kaiser, PhD. Causal Evidence for a Role of Theta and Alpha Oscillations in the Control of Working Memory. I use the methods of cognitive neuroscience to address questions about the interactions between perception, attention, memory, and action. Description. These results identify brain targets for future research and demonstrate that alcohol use and dependence remodel brain-wide functional architecture to decrease modularity. Particular thanks to my officemates over the years (Courtney Gallen, Adam For Justin’s research he addresses the role of neural oscillations in voluntary and automatic cognition. I am also interested in using functional MRI to observe non-invasive brain stimulation with magnetic induction in situ, which requires developing new hardware and software that minimizes the interactions between these two methods. Cooper, U. Hasson, and S.L. Professor, Neurological Surgery, UCSF Weill Institute for Neurosciences, Professor, Department of Integrative Biology, UC Berkeley, The Lactate Shuttle Theory: Relevance for Traumatic Brain Injury & More (interview), Professor of the Graduate School, Department of Physics, UC Berkeley, Professor, Department of Bioengineering, Electrical Engineering & Computer Science, UC Berkeley. The aim of the current study was to investigate the oscillatory neuronal mechanisms underlying two distinct components of hierarchical cognitive control: the level of abstraction of a rule, and the number of rules that must be maintained (set-size). Copyright © 2020 UC Regents; all rights reserved, UCSF Weill Institute for Neurosciences and Director, UCSF Neurorecovery Clinic, The Lactate Shuttle Theory: Relevance for Traumatic Brain Injury & More. The D'Esposito Lab is a cognitive neuroscience research laboratory within theHelen Wills Neuroscience Institute and the Department of Psychology. He's interested in applying data science to the challenges in human neuroscience. At Wheeler LABS, I aim to foster a collaborative environment that allows basic scientists and clinicians to work on shared goals. Prior to graduate school, I was an undergraduate at UC Berkeley, where I worked on decoding object category representations from visual cortex using functional MRI, in the lab of Prof. Mark D’Esposito. Analyses of DDM parameters revealed that patients showed substantially increased non-decision times and reduced response caution during risky choice. Brain Imaging Center (2000-2020) at the Helen Wills Neuroscience Institute at the University of California, Berkeley. Oscillatory amplitude correlated with behavioral performance in the task. The effect of rhythmic TMS on WM performance was dependent on whether the TMS frequency matched or mismatched the expected underlying task-driven oscillations of the targeted region. Lab Manager Hello! Georgia Institute of Technology Lab Website: rahnevlab.gatech.edu 130 J.S. The drift diffusion model as the choice rule in inter-temporal and risky choice: A case study in medial orbitofrontal cortex lesion patients and controls. I am also investigating the different roles of functional and structural disconnections that come with different lesions and their impact on brain network reorganization. In the years before grad school, I worked in homeless counseling and mental health services. Article Causal Contribution of Awake Post-encoding Processes to Episodic Memory Consolidation Arielle Tambini1,2,3,* and Mark D’Esposito1 1Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA 2Department of Neurobiology and Behavior, Center for Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA Phase amplitude coupling analysis revealed that delta phase coupled with beta amplitude during conditions with a higher level of abstraction, whereby beta band may potentially represent motor output that was guided by the delta phase. Email: bbowles2@berkeley.edu. Marc Ettlinger. NOTE - this is no longer meeting in D-Lab. Although our understanding of the neurocircuitry that underlies alcohol use has improved, novel brain regions that are involved in alcohol use and novel biomarkers of alcohol use need to be identified. Functional MRI in the targeted regions predicted subsequent TMS effects across subjects supporting a model by which theta oscillations are excitatory to neural activity, and alpha oscillations are inhibitory. He researches working memory and frontal lobe function, functional MRI, cognitive neuroscience He is the primary investigator for The D'esposito Lab. Visiting Researcher, Department of Psychology, UC Berkeley and  Adjunct Professor, Department of Neurology, UC Davis. We found distinct oscillatory signatures that correspond to two different components of hierarchical control: the level of abstraction of a rule and the number of rules in competition. Interpretation-Mediated Changes in Neural Activity During Language Comprehension. Previous research has suggested that neuronal oscillations at different frequency bands are associated with top-down cognitive control, however, whether distinct neural oscillations have similar or different functions for cognitive control is not well understood. My main interest is the non-invasive stimulation of the brain by magnetic induction. MOOC: Algorithms - Design and Analysis, Part 1. In contrast, vmPFC/mOFC damage abolished neither scaling nor asymptote of the drift rate. Associate Professor in Psychiatry, Harvard Medical School and Associate Biophysicist at McLean Hospital, Belmont MA. Justin Riddle is a graduate student at University of California, Berkeley studying cognitive neuroscience under the supervision of Professor Mark D’Esposito. His lab has developed and implemented a wide range of approaches and methods to study brain function including functional MRI, transcranial magnetic stimulation, electrocorticography, pharmacological interventions and behavioral studies of patients with neurological disorders. The D'Esposito Lab is a cognitive neuroscience research laboratory within the Helen Wills Neuroscience Institute and the Department of Psychology. ... Mark D’Esposito. Distinct oscillatory dynamics underlie different components of hierarchical cognitive control. Finally, the expression of beta amplitude was coordinated via the phase of delta oscillations, and theta phase coupled with gamma amplitude. Dr. Mark D’Esposito is Professor of Neuroscience and Psychology, and Director of the Henry H. Wheeler, Jr. Competition and Control During Working Memory. Ben is a post-doc in Mark D'Esposito's lab. I recently began to investigate markers for brain metabolism using spectroscopy data and the potential changes in stroke patients. Baniqued completed an NIH post-doctoral fellowship at the University of California, Berkeley, in the lab of Mark D’Esposito. Alcohol abuse and alcohol dependence are key factors in the development of alcohol use disorder, which is a pervasive societal problem with substantial economic, medical, and psychiatric consequences. Associate Research Professor. Hierarchical cognitive control enables us to execute actions guided by abstract goals. Cools R, Sheridan M, Jacobs EC, D'Esposito M.Impulsive personality predicts dopamine-dependent changes in fronto-striatal activity during component processes of working memory, Journal of Neuroscience, … Research Collectively, I aim to use these neural markers to predict recovery and rehabilitation. Mark D'Esposito is a professor of Neuroscience and Psychology at the Helen Wills Neuroscience Institute. He is also Director of the Neurorehabilitation Unit at the Northern California VA Health Care System and Adjunct Professor of Neurology at UCSF. Prioritizing relevant information has been linked to theta frequency neural oscillations in lateral prefrontal cortex and suppressing irrelevant information has been linked to alpha oscillations in occipito-parietal cortex [3,11]. Gazzaley A, Cooney J, McEvoy K, Knight RT, D’Esposito M.Top-down modulation of visual processing: converging fMRI and ERP evidence, Journal of Cognitive Neuroscience, 17:507-17, 2005. Model comparison revealed that, for both tasks, the data were best accounted for by a variant of the drift diffusion model including a non-linear mapping from value-differences to trial-wise drift rates. Kimbrough, A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, D'Esposito M, Contet C, George O. Riddle, J, Scimeca JM, Cellier D, Dhanani S, D'Esposito M. Riddle, J, Vogelsang DA, Hwang K, Cellier D, D'Esposito M. Brain-wide functional architecture remodeling by alcohol dependence and abstinence. He has encouraged me to see no obstacle and to learn whatever technique is appropriate Results from time-frequency analysis in frontal electrodes showed an increase in theta amplitude for increased set-size, whereas an increase in delta was associated with increased abstraction. Read more about Ben Bowles; When & Where. I completed my Ph.D. with Tobias Egner at Duke, and postdoctoral research with Mark D’Esposito at UC Berkeley. Small. Mark D'Esposito is a Professor of Neuroscience and Psychology. There he studied how the human brain manages information in working memory and responds to incentives in the form of financial gains and losses. Brain Imaging Center at the UC Berkeley. In 2016, she was awarded an NIH postdoctoral fellowship to examine the representational properties and causal mechanisms of lateral prefrontal function in emotion with Dr. Mark D'Esposito at the University of California, Berkeley. Bio: Dr. Mark D’Esposito is Professor of Neuroscience and Psychology, and founding Director of the Henry H. Wheeler, Jr. Drawing on his training in Neurology, Neuroscience and Psychology, his research focuses on investigating the neural bases of high-level cognitive processes such as working memory and cognitive control, achieved through several different experimental approaches and methodologies. We collected electroencephalography (EEG) data in 31 men and women who performed a hierarchical cognitive control task that varied in levels of abstraction and set-size. Senior Research Data Scientist, To causally test the role of these neural oscillations, we applied rhythmic transcranial magnetic stimulation (TMS) in either theta or alpha frequency to prefrontal and parietal regions identified using functional MRI. Mark D’Esposito, Helen Wills Neuroscience Institute, University of California, Berkeley “A neural blueprint for cognitive control” Thursday January 26, 12:30-1:30pm Howell Hall 205. Working memory (WM) relies on the prioritization of relevant information and suppression of irrelevant information [1, 2]. Location: D-Lab Convening Room. Our project-oriented (ad hoc) teams are driven to provide new tools in medicine or to improve existing tools, and to deploy them in the most efficient way possible, whether through blogs, peer-reviewed publications, patents or startup companies. Mark D’Esposito, MD Professor of Neuroscience and Psychology, and Director of the Henry H. Wheeler, Jr. Both theta and delta amplitude correlated with behavioral performance in the tasks but in an opposite manner: theta correlated with response time slowing when the number of rules increased whereas delta correlated with response time when rules became more abstract. These results suggest that distinct neural oscillatory mechanisms underlie different components of hierarchical cognitive control. He is also an attending neurologist at the Northern California VA Health Care System and Adjunct Professor of Neurology at UCSF. I am investigating abnormal cerebral perfusion and what it means for behavior after stroke. Not currently active. The present study used a single-cell whole-brain imaging approach to 1) assess whether abstinence from alcohol in an animal model of alcohol dependence alters the functional architecture of brain activity and modularity, 2) validate our current knowledge of the neurocircuitry of alcohol abstinence, and 3) discover brain regions that may be involved in alcohol use. Brain Imaging Center at the Helen Wills Neuroscience Institute at the University of California, Berkeley. Brian Galla. My research aims to provide insights into brain metabolism in healthy aging using advanced 1H MR spectroscopy (MRS) methods. Mark D’Esposito, Helen Wills Neuroscience Institute, UC Berkeley David Feinberg, Advanced MRI Technologies and Helen Wills Neuroscience Institute, UC Berkeley Alison Gopnik, Department of Psychology, UC Berkeley Boris Heifets, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine Dr. Mark D’Esposito is Professor of Neuroscience and Psychology, and former Director of the Henry H. Wheeler, Jr. Assistant Professor, Neurology, UCSF Weill Institute for Neurosciences and Director, UCSF Neurorecovery Clinic, Research Associate, Department of Integrative Biology, UC Berkeley and Co-founder & CEO at Medostic, Research Scientist, UC Berkeley and Adjunct Senior Research Fellow, Center for Language and Brain at the National Research University HSE in Moscow, Russia, Associate Professor, Neurology, UCSF Weill Institute for Neurosciences, Director, Institute for Translational Neuroscience and Associate Professor, Departments of Neurology and Psychiatry, UCSF, Manager, Central California 900 MHz NMR Facility, QB3, UC Berkeley, Assistant Professor, Statistics Department and BIDS Senior Fellow, UC Berkeley, Associate Professor, Neurology and Neurosurgery, McGill University, Canada, Professor, Neurology, UCSF Weill Institute for Neurosciences and Director of the UCSF Neurovascular Service. 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